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2025
Kuthethur R, Acharya A†, Sengodan SK†, Fonseca C†, NagarN†, Nasrin SVZ, Ibini O, Manolika EM, de Koning K, Braunshier S, Dessapt J, Fradet-Turcotte A, Lebbink JHG, Kanaar R, Poluri KM, Sharan SK, Cejka P, Chaudhuri AR (2024) FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments,
2024
Yang Y*, Jayaprakash D*, Hollingworth R, Chen S, Nandakumar N, Jablonski AE, Gao Y, Anand JR, Mutter-Rottmayer E, An J, Cheng X, Pearce KH, Blanchet SA, Fradet-Turcotte A, Stewart GS, and Vaziri C§ (2024). A Degenerate PCNA-Interacting Peptide (DPIP) box targets RNF168 to replicating DNA to limit 53BP1 signaling, Nucleic Acids Research, 52(21):13019-13035
Clerf E*, Galloy M*, Fradet-Turcotte A, and Côté J§. (2024) Histone H2A variants play a key role at DNA double-strand breaks during repair pathway choice, Frontiers in Epigenetics and Epigenomic, In Press
Yang Z*, Mameri A*, Cattoglio C, Lachance C, Florez Ariza AJ, Luo J, Humbert J, Sudarshan D, Banerjea A, Galloy M, Fradet-Turcotte A, Lambert JP, Ranish JA, Côté J and Nogales E§ (2024) Unique structural features of the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex, Science, 385(6711):eadl5816
Collin V*, Biquand E*, Tremblay V*, Lavoie EG, Blondeau A, Gravel A, Galloy M, Lashgari A, Dessapt J, Côté J, Flamand L and Fradet-Turcotte A§ (2024) The immediate early protein 1 of the human herpesvirus 6B counteracts NBS1 and prevent homologous recombination repair pathways, EMBO Reports, 25(2):725-744
2023
Pinedo-Carpio E*, Dessapt J*, Beneyton A†, Sacre L†, Bérubé MA, Villot R, Lavoie E, Coulombe Y, Blondeau A, Boulais J, Malina A, Luo V, Lazaratos AM, Côté JF, Mallette FA, Guarné A, Masson JY, Fradet-Turcotte A§, and Orthwein§ A (2023) FIRRM cooperates with FIGNL1 to modulate RAD51 assembly during DNA repair. Science Advances, 9(32):eadf4082
Stok C, Tsaridou S, van den Tempel N, Everts M, Wierenga E, Bakker F, Kok Y, Teles Alves I, T.Jae L, WD Raas M, in ‘t Veld PH, de Boer HR, Bhattacharya A, Karanika E, Warner H, Chen M, van der Kooij B, Dessapt J, ter Morsche L, Perepelkina P, Fradet-Turcotte A, Guryev V, Tromer EC, Chan KL, SN Fehrmann R and van Vugt M(2023). FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics. Cell Reports, 42(7):112668
Binda O, Kimenyi Ishimwe AB, Galloy M, JacquetK, Corpet A, Fradet-Turcotte A, Côté J, and Lomonte P. (2022) The TUDOR domain of SMN is an H3K79me1 histone mark reader. Life Science Alliance, 6(6):e202201752.
Guitton-Sert L*, Gao Y*, Dessapt J, Coulombe Y, Rodrigue A, Blondeau A, Balle Larsen N, Duxin J, Fradet-Turcotte A, and Masson JY. (2023) A CRISPR-Cas9 screen identifies EXO1 as a formaldehyde resistance protein. Comm., 14(1):381
2022
Becht DC*, Klein JB*, Kanai A*, Jang SM*, Cox4 KL, Zhou BR, Phanor SK, Zhang Y, Ebmeier CC, Lachance C, Galloy M, Fradet-Turcotte A, Bulyk ML, Bai Y, Poirier MG, Côté J, Yokoyama A§ and Kutateladze TG§ (2022) MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain. Nat. Comm., 14(1):697
Devoucoux M, Khelifi G, Fort V, Galloy M, Bourriquen G, Fradet-Turcotte A, Hussein SMI*, Côté J* (2021) Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes. Cell Reports, 39(11):110947
Agbo L, Blanchet SA, Pata-Eting Kougnassoukou Tchara, Fradet-Turcotte A, and Lambert JP§ (2022) Comprehensive interactome mapping of nuclear receptors using proximity biotinylation. Methods in Molecular Biology, Geddes-McAlister J (Eds.), Proteomics in System Biology: Methods and Protocols, 2456-223-240
2021
Galloy M*, Lachance C*, Cheng X, Distéfano-Gagné F, Côté J and Fradet-Turcotte A§ (2021) Approaches to study native chromatin-modifying activities and function. Frontiers in Cell and Developmental Biology, section Epigenomics and Epigenetics, 9:729338
Sherker A, Chaudhary N, Adam S, Noordermeer SM, Fradet-Turcotte A and Durocher D (2021) Two redundant ubiquitin-dependent pathways of BRCA1 localization to DNA damage sites. EMBO J., 22(12):e53679
Luthold C, Lambert H, Guilbert SM, Rodrigue MA, Fuchs M, Varlet AA, Fradet-Turcotte A and Lavoie J (2021) CDK1-mediated Phosphorylation of BAG3 Promotes Mitotic Cell Shape Remodeling and the Molecular Assembly of Mitotic p62 bodies, Cells, 10(10):2638
Krassowski M, Pellegrina D, Mee MW, Fradet-Turcotte A, Bhat M, Reimand J. (2021) ActiveDriverDB: interpreting genetic variation in human and cancer genomes using post-translational modification sites and signalling networks (2021 update), Frontiers in Cell and Developmental Biology, special collection on Computational Resources for Understanding Biomacromolecular Covalent Modifications, 9:626821
2019
Salamun SG, Sitz J, De La Cruz-Herrera CF, Yockteng-Melgar J, Marcon E, Greenblatt J, Fradet-Turcotte A, and Frappier L. (2019) The Epstein-Barr Virus BMRF1 Protein Activates Transcription and Inhibits the DNA Damage Response by Binding NuRD. Virol, 93(22):e01070-19
Sitz J, Blanchet SA, Gameiro S, Biquand E, Morgan TM, Galloy M, Dessapt J, Lavoie EG, Blondeau A, Brandon CS, Mymryk J, Moody CA, Fradet-Turcotte A (2019) Human papillomavirus E7 oncoprotein targets RNF168 to subvert DNA damage response. PNAS, 116(39):19552-19562
2018
Ho T, Sitz J, Shen Q, Leblanc-Lacroix A, Campos E, Borozan I, Marcon E, Greenblatt J, Fradet-Turcotte A, Jin D and Frappier L. (2018) A Screen for Epstein-Barr Virus Proteins that Inhibit the DNA Damage Response Reveals a Novel Histone Binding Protein. Virol, 92(14):e00262-18 This article has been selected by the editors of the Journal of Virology for inclusion in the feature “Spotlight” of this issue.
Canny MD, Moatti N, Wan LC, Fradet-Turcotte A, Orthwein A, Juang Y, Zhang W, Noordermeer SM, Wilson MD, Vorybov A, Ernst A, Ng TF, Zimmermann M, Munro M, Sidhu SS, Sicheri F and Durocher D. (2018) Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency. Nature Biotech., 36(1):95-102
Krassowski M, Paczkowska M, Cullion K, Huang T, Dzneladze I, Ouellette F, Yamada JT, Fradet-Turcotte A, Reimand J. (2018) ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. NAR, 46(D1):D901-D910
Weitzman MD† and Fradet-Turcotte A†. (2018) Virus DNA Replication and the host DNA damage response. Ann. Rev. Virol., 5(1):141-164
2017
Kitevski-LeBlanc J*, Fradet-Turcotte A*, Kukic P, Portella G, Yuwen T, Wilson MD, Panier S, Duan S, Canny MD, van Ingen H, Arrowsmith C, Rubinstein JL, Vendruscolo M, Durocher D and Kay LE (2017) The RNF168 paralog RNF169 defines a new class of ubiquitylated-histone reader involved in response to DNA damage. eLife, 6:e23872
2016
Fradet-Turcotte A†, Sitz J, Grapton D and Orthwein A†. (2016) BRCA2 functions: from DNA repair to replication fork stabilization. Endocr Relat Cancer. 23(10):T1-T17
Wilson MD*, Benlekbir S*, Fradet-Turcotte A, Sherker A, Julien JP, McEwan A, Noordermeer SM, Sicheri F, Rubinstein JL, and Durocher (2016) The structural basis of ubiquitylated nucleosome recognition by 53BP1. Nature, 536(7614):100-3.
Jacquet K, Fradet-Turcotte A, Avvakumov N, Lambert JP, Roques C, Paquet E, Gingras AC, Pandita T, Doyon Y, Durocher D and Côté J. (2016). The TIP60 complex regulates bivalent chromatin recognition by 53BP1 through direct H4K20me binding and H2AK15 acetylation. Molecular Cell, 62(3): 409-21
2015
Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth FP, Rissland OS, Durocher D, Angers S and Moffat J. (2015). CRISPR-Cas9 screens reveal genotype-specific cancer vulnerabilities. Cell, 163(6) :1515-26
Lehoux, M., Fradet-Turcotte and J. Archambault. (2015) Methods to assess the nucleocytoplasmic shuttling of the HPV E1 helicase and its effects on cellular proliferation and induction of a DNA damage response. Methods Mol Biol. 1249:67-80.
Gagnon, D., Fradet-Turcotte and J. Archambault. (2015) A quantitative and high-throughput assay of human papillomavirus DNA replication. Methods Mol Biol. 1249:305-16.
2013
Bohgaki M, Bohgaki T, El Ghamrasni S, Srikumar T, Maire G, Panier S, Fradet-Turcotte A, Stewart GS, Raught B, Hakem A and Hakem R. (2013) RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks. Proc Natl Acad Sci U S A., 110(52) : 20982-7
Fradet-Turcotte A, Canny MD, Escribano-Díaz C, Orthwein A, Leung CCY, Huang H, Landry MC, Kitevski-LeBlanc J, Noordermeer SM, Sicheri F and Durocher D. (2013) 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. Nature, 499(7456) : 50-54
- 2025- Editorial Expression of Concerned raised for 2 figures in the supplementary material. Official EEoC: “The Editors would like to alert the readers that concerns have been raised regarding the data presented in Supplementary Figures 6 and 7:
- The flow cytometry plots in Supplementary Fig. 6a appear to have repetitive data point patterns.
- The 53BP1 and Flag lanes 3-5 in Supplementary Fig. 7b appear highly similar (flipped horizontally).
- Although the affected figures do not alter the results or conclusions of the article, readers are advised to interpret these results with caution. The first and corresponding authors are in the process of re-doing these experiments, the results of which will be reported elsewhere.”
Escribano-Díaz C, Orthwein A, Fradet-Turcotte A, Xing M, Young JT, Tkáč J, Cook MA, Rosebrock AP, Munro M, Canny MD, Xu D and Durocher D. (2013) A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Cell., 49(5):872-83
2012
Panier S, Ichijima Y, Fradet-Turcotte A, Leung CC, Kaustov L, Arrowsmith CH and Durocher D. (2012) Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks. Cell., 47(3):383-95
Lehoux M, Fradet-Turcotte A, Lussier-Price M, Omichinski JG and Archambault J. (2012) Inhibition of human papillomavirus DNA replication by an E1-derived p80/UAF1-binding peptide. Virol., 86(7):3486-500
2011
Fradet-Turcotte A, Bergeron-Labrecque F, Lehoux M, Moody CA, Laimins LA and Archambault J. (2011) Nuclear accumulation of the papillomavirus E1 helicase blocks S-phase progression and triggers an ATM-dependent DNA damage response. Virol., 85(17): 8996-9012
D’Abramo, C. M., Fradet-Turcotte, and J. Archambault. (2011) Chapter 11: Human Papillomavirus DNA replication: Insights into the structure and regulation of a eukaryotic DNA replisome. In “Small DNA Tumour Viruses”, Ed. Kevin Gaston, Horizon Press.
Meinke G, Phelan P, Fradet-Turcotte A, Archambault J and Bullock PA. (2011) Structure-based design of a disulfide-linked oligomeric form of the Simian Virus 40 (SV40) large T antigen DNA-binding domain. Acta Crystallographica Section D: Biological Crystallography, 67(6):560-567
Morin G*, Fradet-Turcotte A*, Bergeron-Labrecque F, Di Lello P, Omichinski JG and Archambault J. (2011) A conserved amphipathic helix in the N-terminal regulatory region of the papillomavirus E1 helicase is required for efficient viral DNA replication. Virol., 85(11):5287-5300
Meinke G, Phelan P, Fradet-Turcotte A, Bohm A, Archambault A and Bullock PA. (2011) Structure-based analysis of the interaction between SV40 T-antigen origin binding domain and single stranded DNA. Virol., 85(2):818-27
2010
Fradet-Turcotte A, Moody CA, Laimins LA and Archambault J. (2010) Nuclear export of HPV31 E1 is regulated by Cdk2 phosphorylation and required for viral genome maintenance. Virol., 84(22): 11747-11760
- This article has been selected by the editors of the Journal of Virology for inclusion in the feature “Spotlight” of this issue and to be posted on MDlinx.
Fradet-Turcotte A*, Morin G*, Lehoux M, Bullock PA, and Archambault J. (2010) Development of quantitative and high-throughput assays of polyomavirus and papillomavirus DNA replication. Virology, 399(1):65-76
2009
Fradet-Turcotte A, Brault K, Titolo S, Howley PM and Archambault J. (2009) Characterization of papillomavirus E1 helicase mutants defective for interaction with the SUMO-conjugating enzyme Ubc9. Virology, 395(2):190-201
Gagnon G, Joubert S, Sénéchal H, Fradet-Turcotte A, Torre S and Archambault J. (2009) Proteasomal Degradation of the Papillomavirus E2 Protein is Modulated by Complex Formation with the Bromodomain-Containing Protein 4 (Brd4). Virol., 83(9):4127-39
2008
Di Lello P, Miller Jenkins LM, Mas C, Langlois C, Malitskaya E, Fradet-Turcotte A, Archambault J, Legault P, Omichinski JG. (2008) p53 and TFIIEalpha Share a Common Binding Site of the Tfb1/p62 Subunit of TFIIH. Proc Natl Acad Sci U S A., 105(1):106-11
Côté-Martin A, Moody CA, Fradet-Turcotte A, D’abramo C, Lehoux M, Joubert S, Poirier G, Laimins LA, Coulombe B, Archambault J. (2008) The Human Papillomavirus E1 Helicase Interacts with the WD Repeat Protein p80 to Promote Maintenance of the Viral Genome in Keratinocytes. J Virol., 82(3):1271-83
Moody CA, Fradet-Turcotte A, Archambault J and Laimins LA. (2007) Human Papillomaviruses Activate Caspases upon Epithelial Differentiation to Promote Genome Amplification through Cleavage of the E1 Replication Protein. Proc Natl Acad Sci U S A., 104(49):19541-6
2007
Fradet-Turcotte A, Vincent C, Joubert S, Bullock PA, Archambault J. (2007) A Quantitative Analysis of the Binding of Simian Virus 40 Large T Antigen to DNA. J Virol., 81(17):9162-74
Kumar A, Meinke G, Reese DK, Moine S, Phelan PJ, Fradet-Turcotte A, Archambault J, Bohm A, Bullock PA. (2007) A model for T-antigen dependent melting of the Simian Virus 40 Core Origin based on studies of the interaction of the beta-hairpin with DNA. Virol., 81(9):4808-18
- Used to create a figure in “Principles of Virology”, 3rd ed., (Flint, Enquist, Racaniello and Skalka eds.) (2009). Chapter 9, on “Genome Replication Strategies – DNA viruses”
Fradet-Turcotte A, and Archambault J. (2007) Recent advances in the search for antiviral agents against human papillomavirus. Antiviral therapy. 12(4):431-51