DNA Damage Research


Kitevski-LeBlanc J*, Fradet-Turcotte A*, Kukic P, Portella G, Yuwen T, Wilson MD, Panier S, Duan S, Canny MD, van Ingen H, Arrowsmith C, Rubinstein JL, Vendruscolo M, Durocher D and Kay LE (2017) The RNF168 paralog RNF169 defines a new class of ubiquitylated-histone reader involved in the response to DNA damage. eLife, 6. pii: e23872 [*co-first author]


Fradet-Turcotte A*, Sitz J, Grapton D and Orthwein A*. (2016) BRCA2 functions: from DNA repair to replication fork stabilization. Endocr Relat Cancer, 23(10):T1-T17 [*co-corresponding author]

Wilson MD*, Benlekbir S*, Fradet-Turcotte A, Sherker A, Julien JP, McEwan A, Noordermeer SM, Sicheri F, Rubinstein JL, Durocher D. (2016) The structural basis of modified nucleosome recognition by 53BP1. Nature, 536(7614):100-3 [*co-first author]

Canny MD, Wan LC, Fradet-Turcotte A, Orthwein A, Juang Y, Zhang W, Moatti N, Noordermeer SM, Wilson MD, Vorybov A, Ernst A, Ng TF, Zimmermann M, Munro M, Sidhu SS, Sicheri F and Durocher D. (2016) A genetically encoded inhibitor of 53BP1 to stimulate homology-based gene editing. bioRxiv, doi:10.1101/060954

Jacquet K, Fradet-Turcotte A, Avvakumov N, Lambert JP, Roques C, Pandita RK, Paquet E, Herst P, Gingras AC, Pandita TK, Legube G, Doyon Y, Durocher D, Côté J. (2016) The TIP60 complex regulates bivalent chromatin recognition by 53BP1 through direct H4K20me binding and H2AK15 acetylation. Mol. Cell., 62(3):409-21


Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth FP, Rissland OS, Durocher D, Angers S, Moffat J. (2015) High-resolution CRISPR screens reveal fitness genes and genotype-specific cancer liabilities. Cell, 163(6):1515-26


Orthwein A, Fradet-Turcotte A, Noordermeer SM, Canny MD, Brun CM, Strecker J, Escribano-Diaz C and Durocher D. (2014) Suppression of DNA double-strand break repair in mitosis paradoxically preserves genomic integrity. Science, 344(6180):189-93


Bohgaki M, Bohgaki T, El Ghamrasni S, Srikumar T, Maire G, Panier S, Fradet-Turcotte A, Stewart GS, Raught B, Hakem A and Hakem R. (2013) RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks. Proc Natl Acad Sci U S A., 110(52):20982-7

Fradet-Turcotte A, Canny MD, Escribano-Díaz C, Orthwein A, Leung CCY, Huang H, Landry MC, Kitevski-LeBlanc J, Noordermeer SM, Sicheri F and Durocher D. (2013) 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. Nature, 499(7456):50-54

Escribano-Díaz C, Orthwein A, Fradet-Turcotte A, Xing M, Young JT, Tkáč J, Cook MA, Rosebrock AP, Munro M, Canny MD, Xu D and Durocher D. (2013) A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Mol. Cell., 49(5):872-83

Panier S, Ichijima Y, Fradet-Turcotte A, Leung CC, Kaustov L, Arrowsmith CH and Durocher D. (2012) Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks. Mol. Cell., 47(3):383-95


Virus Research


Gagnon D, Fradet-Turcotte A. and Archambault J. (2015) A quantitative and high-throughput assay of human papillomavirus DNA replication. Methods Mol Biol., (1249):305-16

Lehoux M, Fradet-Turcotte A. and Archambault J. (2015) Methods to assess the nucleocytoplasmic shuttling of the HPV E1 helicase and its effects on cellular proliferation and induction of a DNA damage response. Methods Mol Biol., (1249):67-80


Lehoux M, Fradet-Turcotte A, Lussier-Price M, Omichinski JG and Archambault J. (2012) Inhibition of human papillomavirus DNA replication by an E1-derived p80/UAF1-binding peptide. J. Virol., 86(7):3486-500


Fradet-Turcotte A, Bergeron-Labrecque F, Lehoux M, Moody CA, Laimins LA and Archambault J. (2011) Nuclear accumulation of the papillomavirus E1 helicase blocks S-phase progression and triggers an ATM-dependent DNA damage response. J. Virol., 85(17): 8996-9012

Meinke G, Phelan P, Fradet-Turcotte A, Archambault J and Bullock PA. (2011) Structure-based design of a disulfide-linked oligomeric form of the Simian Virus 40 (SV40) large T antigen DNA-binding domain. Acta Crystallographica Section D: Biological Crystallography, 67(6):560-567

D’Abramo CM, Fradet-Turcotte A, and Archambault J. (2011) Chapter 11: Human Papillomavirus DNA replication: Insights into the structure and regulation of a eukaryotic DNA replisome. In "Small DNA Tumour Viruses", Ed. Kevin Gaston, Horizon Press.

Morin G*, Fradet-Turcotte A*, Bergeron-Labrecque F, Di Lello P, Omichinski JG and Archambault J. (2011) A conserved amphipathic helix in the N-terminal regulatory region of the papillomavirus E1 helicase is required for efficient viral DNA replication. J. Virol., 85(11):5287-5300 [*co-first author]

Meinke G, Phelan P, Fradet-Turcotte A, Bohm A, Archambault A and Bullock PA. (2011) Structure-based analysis of the interaction between SV40 T-antigen origin binding domain and single stranded DNA. J. Virol., 85(2):818-27


Fradet-Turcotte A, Moody CA, Laimins LA and Archambault J. (2010) Nuclear export of HPV31 E1 is regulated by Cdk2 phosphorylation and required for viral genome maintenance. J. Virol., 84(22): 11747-11760

Fradet-Turcotte A*, Morin G*, Lehoux M, Bullock PA, and Archambault J. (2010) Development of quantitative and high-throughput assays of polyomavirus and papillomavirus DNA replication. Virology, 399(1):65-76 [*co-first author]


Fradet-Turcotte A, Brault K, Titolo S, Howley PM and Archambault J. (2009) Characterization of papillomavirus E1 helicase mutants defective for interaction with the SUMO-conjugating enzyme Ubc9. Virology, 395(2):190-201

Gagnon G, Joubert S, Sénéchal H, Fradet-Turcotte A, Torre S and Archambault J. (2009) Proteasomal Degradation of the Papillomavirus E2 Protein is Modulated by Complex Formation with the Bromodomain-Containing Protein 4 (Brd4). J. Virol., 83(9):4127-39


Côté-Martin A, Moody CA, Fradet-Turcotte A, D'abramo C, Lehoux M, Joubert S, Poirier G, Laimins LA, Coulombe B, Archambault J. (2008) The Human Papillomavirus E1 Helicase Interacts with the WD Repeat Protein p80 to Promote Maintenance of the Viral Genome in Keratinocytes. J Virol., 82(3):1271-83


Moody CA, Fradet-Turcotte A, Archambault J and Laimins LA. (2007) Human Papillomaviruses Activate Caspases upon Epithelial Differentiation to Promote Genome Amplification through Cleavage of the E1 Replication Protein. Proc Natl Acad Sci U S A., 104(49):19541-6

Fradet-Turcotte A, Vincent C, Joubert S, Bullock PA, Archambault J. (2007) A Quantitative Analysis of the Binding of Simian Virus 40 Large T Antigen to DNA. J. Virol., 81(17):9162-74

Kumar A, Meinke G, Reese DK, Moine S, Phelan PJ, Fradet-Turcotte A, Archambault J, Bohm A, Bullock PA. (2007) A model for T-antigen dependent melting of the Simian Virus 40 Core Origin based on studies of the interaction of the beta-hairpin with DNA. J. Virol., 81(9):4808-18 

Fradet-Turcotte A, and Archambault J. (2007) Recent advances in the search for antiviral agents against human papillomavirus. Antiviral therapy. 12(4):431-51



We are always looking forward to recruiting Masters and/or PhD students. If you are enthusiastic about training opportunities in the processes that regulate genomic stability during viral infection, please send us a research statement and your CV.